Wardell, Suzanne: search on Z-Library

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1

G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer

Andreano, Kaitlyn J., Wardell, Suzanne E., Baker, Jennifer G., Desautels, Taylor K., Baldi, Robert, Chao, Christina A., Heetderks, Kendall A., Bae, Yeeun, Xiong, Rui, Tonetti, Debra A., Gutgesell, Lau

Journal:

Breast Cancer Research and Treatment

Year:

2020

File:

PDF, 1.45 MB

2020

2

The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: Implications for the treatment and prevention of osteoporosis

Nelson, Erik R., Wardell, Suzanne E., McDonnell, Donald P.

Journal:

Year:

2013

Language:

english

File:

PDF, 700 KB

english, 2013

3

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product

Liberti, Maria V., Dai, Ziwei, Wardell, Suzanne E., Baccile, Joshua A., Liu, Xiaojing, Gao, Xia, Baldi, Robert, Mehrmohamadi, Mahya, Johnson, Marc O., Madhukar, Neel S., Shestov, Alexander A., Chio, I

Journal:

Cell Metabolism

Year:

2017

Language:

english

File:

PDF, 4.73 MB

english, 2017

4

The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy

Suzanne E. Wardell, Jeffrey R. Marks, Donald P. McDonnell

Journal:

Biochemical Pharmacology

Year:

2011

Language:

english

File:

PDF, 968 KB

english, 2011

5

Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader

Wardell, Suzanne E, Nelson, Erik R, Chao, Christina A, Alley, Holly M, McDonnell, Donald P

Journal:

Endocrine Related Cancer

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

6

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer

Pollock, Julie A, Wardell, Suzanne E, Parent, Alexander A, Stagg, David B, Ellison, Stephanie J, Alley, Holly M, Chao, Christina A, Lawrence, Scott A, Stice, James P, Spasojevic, Ivan, Baker, Jennifer

Journal:

Nature Chemical Biology

Year:

2016

Language:

english

File:

PDF, 1.12 MB

english, 2016

7

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Anderson, Grace R., Wardell, Suzanne E., Cakir, Merve, Yip, Catherine, Ahn, Yeong-ran, Ali, Moiez, Yllanes, Alexander P., Chao, Christina A., McDonnell, Donald P., Wood, Kris C.

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018

8

The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor

Andreano, Kaitlyn J., Baker, Jennifer G., Park, Sunghee, Safi, Rachid, Artham, Sandeep, Oesterreich, Steffi, Jeselsohn, Rinath, Brown, Myles, Sammons, Sarah, Wardell, Suzanne E., Chang, Ching-yi, Norr

Journal:

Molecular Cancer Therapeutics

Year:

2020

File:

PDF, 984 KB

2020

9

Targeting mutant estrogen receptors

Wardell, Suzanne E, Norris, John D, McDonnell, Donald P

Journal:

Year:

2019

Language:

english

File:

PDF, 407 KB

english, 2019

10

Validation of histone deacetylase 3 as a therapeutic target in castration-resistant prostate cancer

McLeod, Abigail B., Stice, James P., Wardell, Suzanne E., Alley, Holly M., Chang, Ching-yi, McDonnell, Donald P.

Journal:

Year:

2017

Language:

english

File:

PDF, 2.27 MB

english, 2017

11

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, Amy E., Yu, Yen-Rei A., He, Sisi, Wardell, Suzanne E., Chang, Ching-Yi, Kwon, Sanghoon, Pillai, Ruchita V., McDowell, Hannah B., Thompson, J. Will, Dubois, Laura G., Sullivan, Patrick M., Kemper

Journal:

Nature Communications

Year:

2017

Language:

english

File:

PDF, 672 KB

english, 2017

12

Mechanisms Controlling Agonist and Antagonist Potential of Selective Progesterone Receptor Modulators (SPRMs)

Wardell, Suzanne E, Edwards, Dean P

Journal:

Seminars in Reproductive Medicine

Year:

2005

Language:

english

File:

PDF, 201 KB

english, 2005

13

Glucose Metabolism as a Target of Histone Deacetylase Inhibitors

Wardell, Suzanne E., Ilkayeva, Olga R., Wieman, Heather L., Frigo, Daniel E., Rathmell, Jeffrey C., Newgard, Christopher B., McDonnell, Donald P.

Journal:

Journal of Clinical Endocrinology & Metabolism

Year:

2009

Language:

english

File:

PDF, 60 KB

english, 2009

14

CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC.

Stice, James P, Wardell, Suzanne E, Norris, John D, Yllanes, Alexander P, Alley, Holly M, Haney, Victoria O, White, Hannah S., Safi, Rachid, Winter, Peter S, Cocce, Kimberly J, Kishton, Rigel J, Lawre

Journal:

Molecular Cancer Research

Year:

2017

Language:

english

File:

PDF, 451 KB

english, 2017

15

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer

Cocce, Kimberly J., Jasper, Jeff S., Desautels, Taylor K., Everett, Logan, Wardell, Suzanne, Westerling, Thomas, Baldi, Robert, Wright, Tricia M., Tavares, Kendall, Yllanes, Alex, Bae, Yeeun, Blitzer,

Journal:

Year:

2019

Language:

english

File:

PDF, 5.12 MB

english, 2019

16

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

Wardell, Suzanne E., Nelson, Erik R., McDonnell, Donald P.

Journal:

Year:

2014

Language:

english

File:

PDF, 1024 KB

english, 2014

17

The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer

Donald P McDonnell, Suzanne E Wardell

Journal:

Current Opinion in Pharmacology

Year:

2010

Language:

english

File:

PDF, 345 KB

english, 2010

18

Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine 400

Wardell, Suzanne E., Narayanan, Ramesh, Weigel, Nancy L., Edwards, Dean P.

Journal:

Molecular Endocrinology

Year:

2010

Language:

english

File:

PDF, 322 KB

english, 2010

19

Pharmacokinetic and pharmacodynamic analysis of fulvestrant in preclinical models of breast cancer to assess the importance of its estrogen receptor-α degrader activity in antitumor efficacy

Wardell, Suzanne E., Yllanes, Alexander P., Chao, Christina A., Bae, Yeeun, Andreano, Kaitlyn J., Desautels, Taylor K., Heetderks, Kendall A., Blitzer, Jeremy T., Norris, John D., McDonnell, Donald P.

Journal:

Breast Cancer Research and Treatment

Year:

2019

Language:

english

File:

PDF, 779 KB

english, 2019

20

Mechanisms Controlling Agonist and Antagonist Potential of Selective Progesterone Receptor Modulators (SPRMs)

Wardell, Suzanne E, Edwards, Dean P

Journal:

Seminars in Reproductive Medicine

Year:

2005

File:

PDF, 201 KB

2005

21

Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways

Dean P. Edwards, Suzanne E. Wardell, Viroj Boonyaratanakornkit

Journal:

The Journal of Steroid Biochemistry and Molecular Biology

Year:

2002

Language:

english

File:

PDF, 742 KB

english, 2002

22

Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer

McDonnell, Donald P., Wardell, Suzanne E., Norris, John D.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 580 KB

english, 2015

23

Osteoporosis || Regulation of Bone Cell Function by Estrogens

Wardell, Suzanne E.

Year:

2013

Language:

english

File:

PDF, 766 KB

english, 2013

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